Imidazoline compounds

ABSTRACT

Compound of formula (I): in which R is as defined in the description, as well as their isomers and their pharmaceutically acceptable acid additions salts. Medicinal products containing the same are useful as Imidazoline receptors ligand.

This present invention relates to new imidazoline compounds, to the process for preparing them and to pharmaceutical compositions containing them.

DESCRIPTION OF THE PRIOR ART

From the point of view of chemical structures, the literature provides many examples of imidazoline derivatives.

For example patents JP-08010871 and EP-501074 claim compounds comprising an imidazoline unit, close to those of the present invention, and which are useful as agents for the cross-linking of epoxy resins.

The studies of E Uhlig et al., (Z. Anor. Allg. Chem., 534, (1986), 188-198) present imidazoline derivatives which act as cupric ion-complexing agents.

When they are used in therapy, the imidazoline derivatives are also very widely described.

For example, patent JP-60209571 presents tetrahydropyrimidines and imidazolines with analgesic properties.

Moreover, many publication (J. N. Sengupta et al., Naunyn-Schniedeberg's Arch. Pharmacol., 335 (4), (1987), 391-396; H. Fuder et al., Pharmacol. Adrenoreceptors, (1984), 335-336; R. R. Ruffolo, Eur. J. Pharmacol., 157 (2-3), (1988) 235-239) present pharmacological studies of imidazoline derivatives, ligands of adrenergic receptors.

BACKGROUND OF THE INVENTION

The subject of the present invention is new imidazoline derivatives with an original structure, exhibiting a very high affinity for the imidazoline receptors.

Such derivatives are quite obviously important in the treatment of cardiovascular diseases such as hypertension. Thus, clonidin, widely used for many years in the treatment of high blood pressure is known.

It is known the imidazoline receptors are involved in stimulating the liberation of insulin by the β cells of the pancreas (Schutz et al., Naunyn-Schniedeberg's Arch. Pharmacol., (1989), 340 (6), 712-714).

The importance of ligands of the imidazoline receptors in the treatment of psychiatric and neurological disorders such as depression, Parkinsons's disease and anorexia has also been reported (D. J. Nutt et al., Annals New York Academy of Science, (1995), 125-139).

However, most of the imidazoline derivatives known so far have, besides their affinity for the imidazoline receptors, a high affinity for the adrenergic receptors which causes the appearance of strong cardiovascular effects.

The applicant has now discovered new derivatives with an imidazoline structure, potent ligands of the imidazoline receptors but lacking for the adrenergic receptors.

Accordingly, the compounds of the invention find a particularly important use in therapy for the treatment of pathologies linked to the imidazoline receptors by virtue of their high affinity for the receptors, while lacking side effects of central origin, because of their very low affinity for the adrenergic receptors. As a result, the derivatives of the invention are important in the treatment of cardiovascular diseases, of hypertension but also in the treatment of diabetic disease as well as in the treatment of psychiatric and neurological disorders such as depression, Parkinson's disease and anorexia which was not the case for the imidazolines known in the prior art.

DETAILED DESCRIPTION OF THE INVENTION

More specifically, the present invention relates to the compounds of formula (I): ##STR1## in which R represents: either a phenyl radical of formula (α): ##STR2## in which R₁ represents: either a (C₁ -C₆) alkyl radical, and in this case:

either R₂ represents a hydrogen atom, as well as R₃ and R₅, and in this case R₄ represents a halogen atom,

or R₂ represents a hydrogen atom, as well as R₄ and R₅, and in this case R₃ represents a halogen atom different from chlorine,

or R₂ represents a cyano radical, and R₃, and R₄ and R₅, each represent a hydrogen atom,

or a halogen atom, and in this case:

either R₃ also represents a halogen atom different from R₁, and R₂, R₄ and R₅ each represent a hydrogen atom,

or R₃ represents a hydrogen atom as well as R₂ and R₅, and R₄ then represents a (C₁ -C₆) alkyl radical,

or a hydrogen atom, and in this case:

either R₂, R₃ and R₄ represent simultaneously a hydrogen atom and R₅ represents a phenyl group,

or R₂ and R₃ represent simultaneously a halogen atom different from each other, R₄ and R₅ each a hydrogen atom,

or R₂ represents a halogen atom of a (C₂ -C₆) alkyl or (C₁ -C₆) alkylcarbonyl group, and R₃, R₄ and R₅ each represent a hydrogen atom,

or R₂ represents a hydrogen atom, as well as R₄ and R₅ and in this case, R₃ is chosen from an ethyl, n-propyl, n-butyl, trifluoromethyl, (C₁ -C₆) alkylthio, trifluoromethoxy, phenyl, phenoxy, (C₁ -C₆) acylamino, aminosulfonyl, aminosulfonyl substituted on the nitrogen atom with one or two (C₁ -C₆) alkyl group),

or R₂ represents nitro, R₃ represents hydroxy, R₄ represents halogen and R₅ represents hydrogen,

or R₃ R₅ each represent hydrogen and R₂ and R₄ each represent halogen and cannot both represent chlorine,

or a naphthyl radical of formula (β): ##STR3## in which R₆ represents a halogen atom, a (C₁ -C₆) alkyl group, or a methoxy group,

or a radical chosen from the radicals

indol-5-yl ##STR4## 1-phenyl-1-cyclohexylmethyl, cycloheptyl,

4-(benzothiazol-2-yl)benzyl, and

the radical ##STR5## their isomers, as well as their pharmaceutically acceptable acid addition salts,

it being understood that, (C₁ -C₆) alkyl, (C₂ -C₆) alkyl and (C₁ -C₆) alkylthio radical are understood to mean both the linear radicals and the branched radicals.

Amount the pharmaceutically acceptable acids which can be used to form and addition salt with the compounds of the invention, there may be mentioned, by way of example and with no limitation being implied, hydrochloric, sulfuric, phosphoric, tartaric, malic, maleic, fumaric, oxalic, methanesulfonic, ethanesulfonic, camphoric and citric acids.

The halogens present in the compounds of general formula (I) are chosen from bromine, chlorine, flourine and iodine.

The invention preferably relates to the compounds of formula: ##STR6## in which R₁ represents linear or branched (C₁ -C₆) alkyl group ##STR7## in which R₁ represents a halogen atom or a linear or branched (C₁ -C₆) alkyl group, and R₃ different from R₁ represents a halogen atom, ##STR8## in which R₁ represents a halogen atom and R₄ represents a linear or branched (C₁ -C₆) alkyl radical, ##STR9## in which R₂ and R₃ each represent a halogen atom different from each other, ##STR10## in which R₃ represent a radical chosen from a radical ethyl, n-propyl, n-butyl, trifluoromethyl, (C₁ -C₆) alkylthio, trifluoromethoxy, phenyl, phenoxy, (C₁ -C₆) acylamino, or amionsulfonyl, aminosulfonyl substituted on the nitrogen atom with one or two linear or branched (C₁ -C₆) alkyl groups, ##STR11## in which R₂ represents a halogen atom or a linear or branched (C_(2-C) ₆) alkyl group or a linear or branched (C₁ -C₆) alkylcarbonyl group.

More particularly, the invention relates to the compounds of formula (I) for which R is chosen from the radicals: ##STR12## in which R₆ represents a halogen atom, a linear or branched (C₁ -C₆) alkyl group, or a methoxy group,

for example R represents a 2-methoxy-1-naphthyl group,

5-indolyl,

cycloheptyl.

The invention also relates to the process for the preparation of the compounds of formula (I), wherein a nitrile of formula (II):

    R--C.tbd.N                                                 (II)

in which R is as defined above,

is condensed with ethylenediamine, in the presence of a catalytic quantity of phosphorus pentasulfide,

it being possible for the crude compound thus obtained to be, if desired:

purified according to one or more methods of purification chosen from crystallization, silica gel chromatography, extraction, filtration, passage on charcoal or on resin,

separated, where appropriate, in a pure form or in the form of a mixture, into its possible isomers, according to conventional separation techniques,

and/or converted, by an acid, to pharmaceutically acceptable salts.

The raw materials used in the process for the preparation of the compounds of formula (I) are either commercially available or easily available to persons skilled in the art.

The compounds of formula (I) possess very important pharmacological properties for the clinician and the doctor.

The compounds of the invention and the pharmaceutical compositions containing them have proved to be potent ligands of the I₁ and/or I₂ imidazoline receptors.

The imidazoline receptors are also involved in anemia, particularly sickle cell anemia, and cancerous proliferation.

Moreover, pharmacological studies of the compounds of the invention have demonstrated a complete absence of toxicity in addition to their very high affinity for the imidazoline receptors, which has already been mentioned.

This makes it possible to establish that the compounds of the invention and the pharmaceutical compositions containing them are useful in the treatment of pathologies linked to the central nervous system, and particularly depression, Parkinson's disease, anorexia, cardiovascular pathologies and in particular hypertension, as well as in the treatment of diabetes, obesity, anemia, particularly sickle cell anemia and cancer.

The subject of the present invention is also the pharmaceutical compositions containing the products of formula (I) or, where appropriate, one of their pharmaceutically acceptable acid addition salts in combination with one or more pharmaceutically acceptable excipients.

Among the pharmaceutical compositions according to the invention, there may be mentioned more particularly those which are suitable for oral, parental, nasal, per- or transcutaneous, rectal, perlingual, ocular or respiratory administration and particularly plain or sugar-coated tablets, sublingual tablets, sachets, packets, gelatin capsules, sublingual preparations, lozenges, suppositories, creams, ointments, skin gels, oral or injectable ampoules and aerosols.

The dosage varies according to the sex, age and weight of the patient, the route of administration, the nature of the therapeutic indication, or possible associated treatments and varies between 0.1 mg and 100 mg per 24 hours in 1 or 2 doses, more particularly between 1 and 10 mg, for example between 1 and 2 mg.

The following examples illustrate the invention, but do not limit it in any way.

EXAMPLES 1 TO 30

General procedure:

A mixture consisting of 25 ml of ethylenediamine, 0.01 moles to 0.02 moles of a nitrile and a catalytic quantity (about 0.5 g) of phosphorus pentasulfide is heated under reflux, with stirring, for 4 to 8 hours. The disappearance of the nitrile is followed by thin-layer chromatography. The cooled mixture is poured into 50 ml of cold water. The whole is then extracted with twice 50 ml of dichloromethane. After evaporation of organic fraction, the residue is crystallized from cyclohexane.

By carrying out the procedure as is described in the general and by using the appropriate nitrile, the compounds of the following examples are obtained:

EXAMPLE 1 2-(4-Biphenyl)-Δ² -imidazoline

Yield: 91%

Melting point: 200° C.

EXAMPLE 2 2-(4-Trifluoromethoxyphenyl)-Δ² -imidazoline

Yield: 77%

Melting point: 150° C.

EXAMPLE 3 2-(5-Indolyl)-Δ² -imidazoline

Yield: 60 %

Melting point: 181° C.

EXAMPLE 4 2-(1-Cyclohexyl-1-phenylmethyl)-Δ² -imidazoline

Yield: 41%

Melting point: 178° C.

EXAMPLE 5 2- 4-(Benzothiazol-2yl)benzyl !-Δ² -imidazoline

Yield: 52%

Melting point: 157° C.

EXAMPLE 6 2-(6-Methoxy-2-naphthyl)-Δ² -imidazoline

Yield: 61%

Melting point: 155° C.

EXAMPLE 7 2-Cycloheptyl-Δ² -imidazoline

Yield: 77%

Melting point: 255° C.

EXAMPLE 8 2-(4-Ethylphenyl)-Δ² -imidazoline

Yield: 98%

Melting point: 135° C.

EXAMPLE 9 1-Methyl-4,5-bis(Δ² -imidazoline-2-yl)imidazole

Yield: 84%

Melting point: 162° C.

EXAMPLE 10 2-(4-n-Propylphenyl)-Δ² -imidazoline

Yield: 70%

Melting point: 126° C.

EXAMPLE 11 2-(4-n-Butylphenyl)-Δ² -imidazoline

Yield: 61%

Melting point: 98° C.

EXAMPLE 12 2-(3-Cyano-2methylphenyl)-Δ² -imidazoline

Yield: 78%

Melting point: 144° C.

EXAMPLE 13 2-(4-Phenoxyphenyl)-Δ² -imidazoline

Yield: 56%

Melting point: 129° C.

EXAMPLE 14 2-(3-Chloro-4-fluorophenyl)-Δ² -imidazoline

Yield: 41%

Melting point: 109° C.

EXAMPLE 15 2-(2-Chloro-4-fluorophenyl)-Δ² -imidazoline

Yield: 40%

¹ H NMR δ (ppm): 2.97 and 3.16 (2m, 4H, 2CH₂); 4.93 s, 1H, NH); 6.46 (dd, 1H, J=2.37 and 8.97 Hz, H₅); 6.59 (d, 1H, J=2.37 Hz, H₃); 7.35 (d, 1H, J=8.71 Hz, H₆).

EXAMPLE 16

2-(2-Fluoro-5-methylphenyl)-Δ² -imidazoline

Yield: 40%

Melting point: 85° C.

EXAMPLE 17 2-(4-Ethylthiophenyl)-Δ² -imidazoline EXAMPLE 18 2-(4-Methylthiophenyl)-Δ² -imidazoline

Yield: 72%

Melting point: 158° C.

EXAMPLE 19 2-(2-Methoxy-1-naphthyl)-Δ² -imidazoline

Yield: 70%

Melting point: 157° C.

EXAMPLE 20 2-(4-Trifluoromethylphenyl)-Δ² -imidazoline

Yield: 81%

Melting point: 180° C.

EXAMPLE 21 2-(3-Ethylphenyl)-Δ² -imidazoline EXAMPLE 22 2-(2-Phenylphenyl)-Δ² -imidazoline EXAMPLE 23 2-(5-Fluoro-2-methylphenyl)-Δ² -imidazoline EXAMPLE 24 2-(4-Hydroxy-5-iodo-3-nitrophenyl)-Δ² -imidazoline EXAMPLE 25 2-(4-Aminosulfonylphenyl)-Δ² -imidazoline EXAMPLE 26 2-(4-Acetylaminophenyl)-Δ² -imidazoline EXAMPLE 27 2-(4-Methyl-1-naphthyl)-Δ² -imidazoline EXAMPLE 28 2-(4-Fluoro-1naphthyl)-Δ² -imidazoline EXAMPLE 29 2-(4-Bromo-2-methylphenyl)-Δ² -imidazoline EXAMPLE 30 2-(3,5-Difluorophenyl)-Δ² -imidazoline PHARMACOLOGICAL STUDY EXAMPLE A Pattern of binding to the I₁ and I₂ imidazoline receptors

Objective:

To measure, in vitro, the binding affinity of the compounds of the invention to the I₁ and I₂ receptors, by determining the capacity of these compounds to displace radioligands specific for the I₁ and I₂ imidazoline receptors.

Protocol:

The following table indicates the radioligand used to label the receptor, the product and the concentration selected to determine the non specific and the tissue chosen.

    ______________________________________     Receptor     or site            Radioligand Non specific                                   Structure     ______________________________________     I.sub.1             .sup.3 H!-Clonidine +                        10.sup.-5 M                                   Bovine Adrenal Medulla            10 μM of Cold clonidine            norepinephrine     I.sub.2             .sup.3 H!-Idazoxan +                        10.sup.-5 M                                   Rabbit renal cortex            10 μM of Idazoxan            norepinephrine     ______________________________________

Results:

The results obtained in vitro on the central or peripheral receptors and with out experimental conditions show that the compounds of the invention have a very high affinity of the I₁ and/or I₂ sites of rabbit renal cortex with K_(i) values from a few nM to a few hundreds of nM.

EXAMPLE B Pattern of binding to the α₁ and α₂ adrenergic central receptors

Objective:

To measure, in vitro, the binding affinity of the compounds of the invention to the α₁ and α₂ central receptors, by determining the capacity of the product to displace radioligands specific for these receptors.

Protocol:

The following table indicates the radioligand used to label the receptor, the product and the concentration selected to determine the nonspecific fraction and the tissue chosen.

    ______________________________________     Receptor or     site     Radioligand Non specific                                     Structure     ______________________________________     α.sub.1               .sup.3 H!-Prazosin                          10.sup.-5 M                                     Calf frontal cortex                          Phentolamine     α.sub.2               .sup.3 H!-RX                          10.sup.-5 M                                     Calf frontal cortex              821002      Yohimbine     ______________________________________

Results:

The results obtained, in vitro on the adrenergic receptors with our experimental conditions, show that the compounds of the invention have only a very low affinity for the α₁ -adrenergic receptors (K_(i) >7 μM) and α₂ -adrenergic receptors (K_(i) >10 μM).

EXAMPLE C Test of behavioral despair

The mice used for this test are placed in a cylinder filled with water from which they cannot escape. After a few efforts to get out, the animals become resigned and stay still, now making only the movement necessary to keep the head out of the water. The animals, in groups of ten, are placed in the cylinder for 6 minutes, and the duration of immobility is measured during the last 4 minutes.

The duration of immobility makes it possible to characterize the antidepressive activity of the test compounds. Thus, antidepressants such as imipramine or desipramine decrease this duration of immobility.

The compounds of the invention showed an activity comparable to that of imipramine and desipramine, the duration of immobility measured being of the same order as that obtained with the reference products.

EXAMPLE D Measurement of affinity for monoamine oxidase

In vitro

The test of binding to the I₂ imidazoline site as well as the affinity for monoamine oxidase are carried out according to the protocol described by C. Carpene (Annals. N.Y. Acad. Sci., 1995, 763, p. 380).

The reference radioligand used is titivated BFI. Competitive binding experiments are carried out with the compounds of the invention with the aim of demonstrating their capacity to displace the reference radioligand.

Ex vivo

The animals used are genetically obese Zucker rats which are subjected to a subchronic treatment with the test compounds. At the end of this test, the binding to the I₂ imidazoline sites as well as the monoamine oxidase activity are measured after extraction of the adipose tissue ex vivo according to a method described by C. Carpene (J. lipids. Res., 1990, 31, p. 811).

Results

It appears that the compounds of the invention possess a high affinity for the I₂ imidazoline binding sites, of the order 1 to 100 nM, and an inhibitory effect on monoamine oxidase in the adipocytes by binding to the enzyme with an affinity of the order of 10⁻⁶ M.

EXAMPLE E Hypoglycemia activity

The hypoglycemia activity of the derivatives of the invention were tested on three-month-old Witsar male rats of about 250 g. An experimental diabetes is obtained by iv injection of a weak dose of streptozotocin dissolved in a citrate buffer (171) under Ketamine hydrochloride anesthesia (75 mg.kg⁻¹, IP). These rats are called "STZ", and the normal rats received an injection of citrate buffer under the same conditions.

Homeostasis was evaluated by a test of glucose tolerance carried out two weeks after injection of streptozotocin.

Intravenous glucose tolerance test (IVGTT)

The glucose is dissolved in a 0.9% aqueous NaCl solution and administered through the saphenous vein to rats anesthetized with pentobarbital (60 mg.kg⁻¹, IP). Blood samples are collected sequentially through the tail vessels before and 5, 10, 15, 20 and 30 minutes after the injection of glucose. They are then centrifuges and the plasma is separated. The plasma glucose concentration is determined immediately on a 10 μl aliquot and the remaining plasma is stored at -20° C.

A single IP injection of the test product is made into rats anesthetized with pentobarbital, 20 minutes before the IVGTT.

Oral glucose tolerance test (OGTT)

The glucose is administered per os (2 g.kg⁻¹) to wakeful rats. Blood samples are collected before and 10, 20, 30, 40, 60, 90 and 120 minutes after the administration of glucose. The treatment of the blood samples is identical to that described above. The test product is administered per os 30 minutes before the OGTT.

Analytical methods

The plasma glucose concentration is determined using a glucose analyzer (Beckman Inc., Fullerton, Calif.). Glucose tolerance is measured in relation to two parameters: ΔG and K. ΔG represents the increase in glycemia above the base line, integrated over a period of 30 minutes (IVGTT) or of 120 minutes (OGTT), after excessive accumulation of glucose. K is the speed of disappearance of glucose between 5 and 30 minutes (IVGTT), after administration of glucose. The coefficient K is calculated only during the IVGTT. It appears that the compounds of the invention have an activity comparable to that of gliclazide, and have the advantage of not inducing the same basal hypoglycemia.

EXAMPLE F Study of acute toxicity

The acute toxicity was assessed after oral administration to lots of 8 mice (26±2 grams) of increasing doses of the product to be studies. The animals were observed at regular intervals during the first day and daily during the two weeks following the treatment. It appears that the compounds of the invention exhibit very little toxicity.

EXAMPLE G Pharmaceutical composition: tablets

Preparation formula for 1000 tablets containing 1 mg doses 2-(4-ethylphenyl)-Δ² -imidazoline:

2-(4-Ethylphenyl)-Δ² -imidazoline . . . 1 g

Wheat starch . . . 20 g

Maize starch . . . 20 g

Lactose . . . 30 g

Magnesium stearate . . . 2 g

Silica . . . 1 g

Hydroxypropylcellulose . . . 2 g 

We claim:
 1. A compound selected from those of formula (I): ##STR13## in which R represents: either a phenyl radical of formula (60 ): ##STR14## in which R₁ represents: either (C₁ -C₆) alkyl, and in this case:R₂ represents cyano, and R₃, R₄ and R₅, each represent hydrogen, or a halogen atom, and in this case:either R₃ also represents a halogen atom different from R₁, and R₂, R₄ and R₅ each represent a hydrogen atom, or R₃ represents a hydrogen atom as well as R₂ and R₅, and R₄ then represents a (C₁ -C₆) alkyl radical, or hydrogen, and in this case:either R₂, R₃ and R₄ represent simultaneously hydrogen and R₅ represents phenyl, or R₂ and R₃ different from each other represent simultaneously halogen, and R₄ and R₅ each represent hydrogen, or R₂ represents (C₂ -C₆) alkyl or (C₁ -C₆) alkylcarbonyl, and R₃, R₄ and R₅ each represent hydrogen, or R₂ represents hydrogen, as well as R₄ and R₅, and in this case, R₃ is chosen from ethyl, n-propyl, n-butyl, trifluoromethyl, (C₁ -C₆) alkylthio, trifluoromethoxy, phenyl, phenoxy, (C₁ -C₆) acylamino, aminosulfonyl, aminosulfonyl substituted on the nitrogen atom with one or two (C₁ -C₆ alkyl), or R₂ represents nitro, R₃ represents hydroxy, R₄ represents halogen, and R₅ represents hydrogen, or R₃ and R₅ each represent hydrogen and R₂ and R₄ each represent halogen and cannot both represent chlorine, or a naphthyl radical of formula (β): ##STR15## in which R₆ represents halogen, (C₁ -C₆) alkyl, or methoxy, or a radical chosen from the radicals1-cyclohexyl-1-phenylmethyl, and cycloheptyl, their optical isomers, or their pharmaceutically acceptable-acid addition salt, it being understood that, (C₁ -C₆) alkyl, (C₂ -C₆) alkyl, and C₁ -C₆ alkylthio are understood to mean both linear and branched radicals.
 2. A compound of claim 1 of formula (αI/a): ##STR16## in which R₁ represents linear or branched (C₁ -C₆) alkyl, their optical isomers, or their pharmaceutically acceptable acid addition salts.
 3. A compound of claim 1 of formula (αI/a): ##STR17## in which R₁ represents halogen and R₃ different from R₁ represents halogen, their optical isomers or their pharmaceutically-acceptable acid addition salts.
 4. A compound of claim 1 of formula (αI/c): ##STR18## in which R₁ represents halogen and R₄ represent linear or branched (C₁ -C₆) alkyl, their optical isomers, or their pharmaceutically-acceptable acid addition salts.
 5. A compound of claim 1 of formula (αI/d): ##STR19## in which R₂ and R₃ represent halogen different from each other, their opticals isomers or their pharmaceutically-acceptable acid addition salts.
 6. A compound of claim 1 of formula (αI/e): ##STR20## in which R₃ represents a radical chosen from ethyl, n-propyl, n-butyl, trifluoromethyl, (C₁ -C₆) alkylthio, trifluoromethoxy, phenyl, phenoxy, (C₁ -C₆) acylamino, or amionsulfonyl, aminosulfonyl substituted on the nitrogen atom with one or two linear or branched (C₁ -C₆) alkyl, their optical isomers or their pharmaceutically-acceptable acid addition salts.
 7. A compound of claim 1 of formula (αI/f): ##STR21## in which R₂ represents linear or branched (C₂ -C₆) alkyl or linear or branched (C₁ -C₆) alkylcarbonyl, their optical isomers or their pharmaceutically-acceptable acid addition salts.
 8. A compound of claim 1 for which R represents a radical β ##STR22## in which R₆ represents halogen, linear or branched (C₁ -C₆) alkyl, or methoxy, their optical isomers, or their pharmaceutically-acceptable acid addition salts.
 9. A compound of claim 1 which is selected from 2-(4-biphenyl)-Δ² -imidazoline or addition salts thereof with a pharmaceutically-acceptable acid.
 10. A compound of claim 1 which is selected from 2-(3-cyano-1-methylphenyl)-Δ² -imidazoline or addition salts thereof with a pharmaceutically-acceptable acid.
 11. A compound of claim 1 which is selected form 2-(4-phenoxyphenyl)-Δ² -imidazoline or addition salts thereof with a pharmaceutically-acceptable acid.
 12. A compound of claim 1 which is selected from 2-(4-ethylphenyl)-Δ² -imidazoline or addition salts thereof with a pharmaceutically-acceptable acid.
 13. A pharmaceutical composition useful as a ligand of imidazoline receptors comprising as active principle an effective amount of a compound as claimed in claim 1, together with one or more pharmaceutically-acceptable excipients or vehicles.
 14. A method for treating a living body afflicted with a diabetic condition comprising the step of administering to the living body an amount of a compound of claim 1 which is effective for alleviation of the said condition.
 15. A compound of claim 1 in which is selected from 2-(1-Cyclohexyl-1-phenylmethyl)-Δ² -imidazoline or pharmaceutically-acceptable acid addition salts thereof.
 16. A compound of claim 1 which is selected from 2-Cycloheptyl-Δ² -imidazoline or pharmaceutically-acceptable acid addition salts thereof. 